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NFL picks spread refers to the betting line set by sportsbooks to level the playing field between two teams. The spread indicates how many points the favored team is expected to win by, allowing bettors to wager on either side. For example, if a team is favored by 7 points, they must win by more than that margin for a bet on them to pay off. Conversely, the underdog can either win outright or lose by fewer points than the spread for a bet on them to be successful. Understanding the spread is crucial for informed betting decisions.